Isabel Villanueva is one of the best violists of the new generation. She is valued for her expression and sensibility as well as for her passion and commitment to promote the viola as an instrument with its own voice. She has appeared as a soloist with the Spanish Radio Television Symphony Orchestra, Moscow Soloists, Estonian National Symphony Orchestra, New Russia State Symphony Orchestra, Orquestra Nacional d’Andorra, Orquesta Sinfónica de Castilla y León, Lebanese Philharmonic Orchestra, among others, under the baton of maestros Salvador Brotons, Andres Mustonen or Michel Plasson, with whom she peformed Walton Viola Concerto last season 16/17 with the Spanish RTVE Symphony Orchestra broadcasted by TVE. She has a wide range repertoire from baroque period to several symphonic world premieres such as José Zárate and Houtaf Khoury Viola Concertos, dedicated to her.

Villanueva has appeared as a soloist and recitalist in Europe, Asia, Russia and Middle East, in prestigious venues including the Grand Hall of St. Petersburg Philharmonic, Xinghai Concert Hall in Guangzhou, Bath Music Festival, Estonia Concert Hall, Auditorio Nacional in Madrid, Palau de la Música Catalana, Santander Festival, Rottweil Musikfestival, Slovenian Philharmonic Hall, Schubertiade RTS, Lavaux Classic Festival, Royal Court Theatre in Copenhagen, Schubertíada in Vilabertrán, Musika-Música in Bilbao, Assembly Hall in Beirut, Roudaki Hall in Tehran (becoming in 2013 the first foreign violist to perform solo recitals in Iran) and the Wigmore Hall in London, among others.

She has a strong interest in expanding music for viola. Premieres and collaborations include solo works by Gubaidulina, Olivero, Zárate, Sotelo, Khoury and Khayam. As a chamber musician she has performed together with Prazak Quartet, Vlach Prague Quartet, Daniel Schnyder, Martti Rousi, Trío Arbós, among others. Her concerts have been broadcasted by RTVE, Catalunya Música, RTV Slovenia, TV Szombathely, Estonia Klassika Raadio, RTV Lebanon, TV Russia Kultura and Swiss RTS.

Awarded the Spanish National Radio Culture Prize 2015 (Premio Ojo Crítico), plays an Enrico Catenar viola from 1670.